我公司致力于為客戶提供高純度、低成本的活性重組蛋白，包括重組人S100A12在內(nèi)的各類受體、細(xì)胞因子、生長因子、轉(zhuǎn)錄因子、激素、酶、毒性蛋白、病毒抗原等。

北京百奧萊博科技有限公司是一家專業(yè)的生物試劑銷售公司。公司主要經(jīng)營血清、抗原、抗體等生物試劑產(chǎn)品，可以為您提供專業(yè)的技術(shù)服務(wù)，以優(yōu)良的價(jià)格、優(yōu)質(zhì)的服務(wù)、優(yōu)先的理念，滿足客戶的各方面的需求，與國內(nèi)多家企業(yè)、單位建立了良好的長期合作關(guān)系，擁有較好的企業(yè)信譽(yù)和品牌形象。 主營產(chǎn)品:血清、抗體、抗原、核酸提取、核酸純化等生化試劑

特別提示：包括重組人S100A12(S100鈣結(jié)合蛋白A12)在內(nèi)，本公司的所有產(chǎn)品僅可用于科研實(shí)驗(yàn)，嚴(yán)禁用于臨床醫(yī)療及其他非科研用途！

產(chǎn)品名稱：重組人S100A12(S100鈣結(jié)合蛋白A12)
英文名稱：Recombinant Human S100 calcium-binding protein A12
產(chǎn)品貨號：JN1298
產(chǎn)品規(guī)格：10μg|50μg|500μg|1mg

本品由我們的大腸桿菌表達(dá)系統(tǒng)制備而成，目的基因編碼的Met1-Glu92表達(dá)純化得來。

S100A12質(zhì)量控制：＞95%(還原性SDS-PAGE)

S100A12制劑：凍干品

S100A12保存：
凍干蛋白置于-20℃以下可長期保存，室溫條件下可穩(wěn)定保存3周。
復(fù)溶蛋白溶液可在4～7℃保存2～7天，可分裝后置于-20℃保存三個(gè)月。

S100A12復(fù)溶：
打開試劑管前請先離心。
復(fù)溶濃度推薦大于100 μg/ml。
凍干蛋白請溶于ddH2O。
復(fù)溶后，請根據(jù)用量分裝凍存，避免反復(fù)凍融。

關(guān)于S100A12：
Human EN-RAGE belongs to the S100/calgranulin superfamily. There are at least 21 different S100 proteins and the protein is soluble in ammonium sulfate at neutral pH. S100 proteins play a role in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response.Human EN-RAGE is characterized by two EF-hand calcium-binding motifs, zinc- and copper-binding protein.S100A12 is a disulfide-linked homodimer and the interface between the two subunits is composed mostly of hydrophobic residues.Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. EN-RAGE acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. It also acts as a monocyte and mast cell chemoattractant. Moreover, it can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. It can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn2+from their active sites.

根據(jù)您的關(guān)注的重組人S100A12(S100鈣結(jié)合蛋白A12)，重組人S100鈣結(jié)合蛋白A12，重組S100鈣結(jié)合蛋白A12，S100鈣結(jié)合蛋白A12，重組S100A12，重組人S100A12(S100鈣結(jié)合蛋白A12)，rhS100A12，重組人S100 calcium-binding protein A12，重組人S100A12，rS100A12，重組S100 calcium-binding protein A12，Recombinant Human S100 calcium-binding protein A12，JN1298，百奧萊博，，，您可能還對以下產(chǎn)品有需求：


JN0307 重組人趨化因子CXCL12(SDF-1β) 10μg|50μg|500μg|1mg
JN0320 重組小鼠趨化因子CCL24(Eotaxin-2) 10μg|50μg|500μg|1mg
JN0354 重組人白介素IL-33(白細(xì)胞介素33) 10μg|50μg|500μg|1mg
JN0418 重組小鼠白介素IL-4(C端帶His標(biāo)簽) 10μg|50μg|500μg|1mg
JN0490 重組人OX40(TNFRSF4)(CD134)(C端His標(biāo)簽) 10μg|50μg|500μg|1mg
JN1929 重組人脂肪酸結(jié)合蛋白1(FABP1) 10μg|50μg|500μg|1mg
JN0519 重組人柯薩奇-腺病毒受體(CAR) 10μg|50μg|500μg|1mg

關(guān)注重組人S100A12(S100鈣結(jié)合蛋白A12)，重組人S100鈣結(jié)合蛋白A12，重組S100鈣結(jié)合蛋白A12，S100鈣結(jié)合蛋白A12，重組S100A12，重組人S100A12(S100鈣結(jié)合蛋白A12)，rhS100A12，重組人S100 calcium-binding protein A12，重組人S100A12，rS100A12，重組S100 calcium-binding protein A12，Recombinant Human S100 calcium-binding protein A12，JN1298，百奧萊博，，的同時(shí)，為您推薦更多您可能感興趣的產(chǎn)品：

貨號	名稱	規(guī)格
JN0216	重組小鼠堿性FGF(成纖維生長因子)	10μg|50μg|500μg|1mg
JN0248	重組人TDGF1(畸胎瘤衍生生長因子)	10μg|50μg|500μg|1mg
JN0341	重組小鼠白介素IL-1α(白細(xì)胞介素1α)	10μg|50μg|500μg|1mg
JN0478	重組小鼠TNFRSF10B	10μg|50μg|500μg|1mg
JN0486	重組小鼠OX40(TNFRSF4)(N端Fc標(biāo)簽)	10μg|50μg|500μg|1mg
JN2013	重組人CDK4抑制劑C(CDKN2C)	10μg|50μg|500μg|1mg

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