我公司致力于為客戶提供高純度、低成本的活性重組蛋白，包括重組Ecotin在內(nèi)的各類受體、細胞因子、生長因子、轉(zhuǎn)錄因子、激素、酶、毒性蛋白、病毒抗原等。

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產(chǎn)品名稱：重組Ecotin
英文名稱：Recombinant E. coli Ecotin
產(chǎn)品貨號：JN1657
產(chǎn)品規(guī)格：10μg|50μg|500μg|1mg

本品由我們的大腸桿菌表達系統(tǒng)制備而成，目標蛋白包含序列(Met1-Arg162)在C端帶有His標簽。

Ecotin質(zhì)量控制：＞95%(SEC-HPLC，還原性SDS-PAGE)


Ecotin制劑：凍干品

Ecotin保存：
凍干蛋白長期保存應(yīng)置于-20℃以下，常溫可穩(wěn)定保存3周。
復(fù)溶蛋白溶液可在4℃保存2～7天。
復(fù)溶后的蛋白溶液應(yīng)盡量避免反復(fù)凍融，可根據(jù)使用量分裝凍存在-20℃以下長達3個月。

Ecotin復(fù)溶：
打開試劑管前請先離心。
復(fù)溶濃度推薦大于100 μg/ml。
Dissolve the lyophilized protein in 1X PBS.
復(fù)溶后，請根據(jù)用量分裝凍存，避免反復(fù)凍融。

關(guān)于Ecotin：
Ecotins are dimeric periplasmic proteins from Escherichia coli and related Gram-negative bacteria that have been shown to be potent and general inhibitors of many trypsin-fold serine proteases of widely varying substrate specificity, which belong to MEROPS peptidase family S1. Ecotin protein inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases and has been characterized as an extremely potent anticoagulant and reversible tight-binding inhibitor of human factor Xa (FXa). The power of inhibition is not linked to specific protease specificity. Immobilized Ecotin has been used to affinity-purify recombinant trypsinogen, indicating that it may also be used to purify additional serine protease zymogens. Compared to other serine protease inhibitors such as members of the serpin family, the reactive site of ecotin is Met104 (P1). Phylogenetic analysis suggested that Ecotin has an exogenous target, possibly neutrophil elastase. Ecotin from E. coli, Yersinia pestis, and Pseudomonas aeruginosa, all species that encounter the mammalian immune system, inhibit neutrophil elastase strongly while ecotin from the plant pathogen Pantoea citrea inhibits neutrophil elastase 1000-fold less potently. Ecotins all potently inhibit pancreatic digestive peptidases trypsin and chymotrypsin, while showing more variable inhibition of the blood peptidases Factor Xa, thrombin, and urokinase-type plasminogen activator. Ecotin is synthesized as a 162 amino acid precursor with a 20 amino acid signal peptide necessary to direct it to the periplasmic space. The mature protein (residues 21 - 162) is expressed and purified.

根據(jù)您的關(guān)注的重組Ecotin，重組Ecotin，Recombinant E. coli Ecotin，重組E. coli Ecotin，JN1657，百奧萊博，，，您可能還對以下產(chǎn)品有需求：



名稱：重組人SHH(音猬因子)
貨號：JN0229
規(guī)格：10μg|50μg|500μg|1mg
本品由我們的大腸桿菌表達系統(tǒng)制備，目的基因編碼的Cys24-Gly197表達純化而來。

SHH質(zhì)量控制：＞95%(還原性SDS-PAGE)。

SHH制劑：凍干品

SHH保存：
凍干蛋白可在-20℃長期保存，室溫也可穩(wěn)定保存3周。
復(fù)溶蛋白溶液可在4～7℃保存2～7天。
復(fù)溶后建議分裝凍存在-20℃，可保存3個月，應(yīng)避免反復(fù)凍融。

SHH復(fù)溶：
1、試劑開蓋前請先離心。
2、復(fù)溶濃度應(yīng)大于100 μg/ml.
3、凍干蛋白溶于ddH2O中
4、復(fù)溶后根據(jù)使用量分裝保存，避免反復(fù)凍融。

關(guān)于SHH：
Sonic Hedgehog Homolog (SHH) belongs to a three-protein family called hedgehog. The other two family members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH). Hedgehog proteins are key signaling molecules in embryonic development. SHH is expressed in various embryonic tissues and plays critical roles in regulating the patterning of many systems, such as limbs and brain. SHH also plays an important role in adult, including the division of adult stem cells and the development of certain cancers and other diseases. Human SHH is expressed as a 45kDa precursor, and undergoes a series of processing during secretion. After the removal of the signal peptide, a protease within the C-terminal domain catalyzes the cleavage of SHH into a 20 kDa N-terminal signaling domain (SHH-N) and a 25 kDa C-terminal domain (SHH-C). SHH-N has the “all signaling” capability. SHH-N binds to the 12 pass transmembrane protein Patched (Ptc) on cell surface, which releases the repression of the activity of Smoothened (Smo), a G-protein coupled receptor, by Ptc.

關(guān)注重組Ecotin，重組Ecotin，Recombinant E. coli Ecotin，重組E. coli Ecotin，JN1657，百奧萊博，，的同時，為您推薦更多您可能感興趣的產(chǎn)品：


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