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產(chǎn)品名稱:重組小鼠補體C5
英文名稱:Recombinant Mouse Complement Compo
nent C5
產(chǎn)品貨號:JN1904
產(chǎn)品規(guī)格:10μg|50μg|500μg|1mg
本品由我們的大腸桿菌表達系統(tǒng)制備而成,目的基因編碼的Asn679-Arg755表達純化得來。
Complement C5質(zhì)量控制:>95%(還原性SDS-PAGE)
Complement C5制劑:凍干品
Complement C5保存:
凍干蛋白置于-20℃以下可長期保存,室溫條件下可穩(wěn)定保存3周。
復溶蛋白溶液可在4~7℃保存2~7天,可分裝后置于-20℃保存三個月。
Complement C5復溶:
打開試劑管前請先離心。
復溶濃度推薦大于100 μg/ml。
凍干蛋白請溶于ddH2O。
復溶后,請根據(jù)用量分裝凍存,避免反復凍融。
關(guān)于Complement C5:
Mouse Complement C5 (C5a) is a glycoprotein that belo
ngs to a family of structurally and functio
nally related proteins known as anaphylatoxins. C5a is a 77 amino acid peptide that is created by the C5a co
nvertase proteolytic cleavage of C5 αchain in the classical and alternative complement pathway (C4b2a3b, C3bBb3b). Mouse C5a has fourαhelices, plus three intra-chain disulfide bo
nds that form a triple loop structure. C5a functions via G-protein coupled receptor (GPCR) (C5aR/CD88). C5a is a potent chemoattractant and anaphylatoxin that acts on all classes of leukocytes and on many other cell types including endothelial, smooth muscle, kidney, liver, and neural cells. It mediates IL-8 release from bro
nchial epithelial cells. It also triggers an oxidative burst in macrophages and neutrophils, causing release of histamine in basophils and mast cells. C5a anaphylatoxin activity on hepatocytes results indirectly from interaction with no
nparenchymal cell via prostanoid secretion. Mouse C5a shares 60% and 82% sequence identity to human and rat C5a, respectively.
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重組小鼠補體C5,重組小鼠Complement Compo
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重組小鼠補體C5,重組小鼠Complement Compo
nent C5,Recombinant Mouse Complement Compo
nent C5,重組小鼠補體C5,重組Complement Compo
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