我公司致力于為客戶提供高純度、低成本的活性重組蛋白，包括重組小鼠TIGIT在內(nèi)的各類受體、細(xì)胞因子、生長(zhǎng)因子、轉(zhuǎn)錄因子、激素、酶、毒性蛋白、病毒抗原等。

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特別提示：包括重組小鼠TIGIT在內(nèi)，本公司的所有產(chǎn)品僅可用于科研實(shí)驗(yàn)，嚴(yán)禁用于臨床醫(yī)療及其他非科研用途！

產(chǎn)品名稱：重組小鼠TIGIT
英文名稱：Recombinant Mouse T cell Immunoreceptor with Ig and ITIM domains
產(chǎn)品貨號(hào)：JN1420
產(chǎn)品規(guī)格：10μg|50μg|500μg|1mg

本品由我們的哺乳動(dòng)物細(xì)胞表達(dá)系統(tǒng)制備而成，目的基因編碼的Gly26-Phe135在C端含有His標(biāo)簽。

TIGIT 質(zhì)量控制：＞95%(還原性SDS-PAGE)

TIGIT 制劑：凍干品

TIGIT 保存：
凍干蛋白置于-20℃以下可長(zhǎng)期保存，室溫條件下可穩(wěn)定保存3周。
復(fù)溶蛋白溶液可在4～7℃保存2～7天，可分裝后置于-20℃保存三個(gè)月。

TIGIT 復(fù)溶：
打開試劑管前請(qǐng)先離心。
復(fù)溶濃度推薦大于100 μg/ml。
凍干蛋白請(qǐng)溶于ddH2O。
復(fù)溶后，請(qǐng)根據(jù)用量分裝凍存，避免反復(fù)凍融。

關(guān)于TIGIT ：
T cell immunoreceptor with Ig and ITIM domains (TIGIT), also called WUCAM, VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells (DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower affinity, but not CD113 (PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.

根據(jù)您的關(guān)注的重組小鼠TIGIT，重組小鼠T cell Immunoreceptor with Ig and ITIM domains，重組小鼠TIGIT，Recombinant Mouse T cell Immunoreceptor with Ig and ITIM domains，重組T cell Immunoreceptor with Ig and ITIM domains，JN1420，百奧萊博，，，您可能還對(duì)以下產(chǎn)品有需求：



名稱：重組小鼠趨化因子CXCL15
貨號(hào)：JN0330
規(guī)格：10μg|50μg|500μg|1mg
本品由我們的哺乳動(dòng)物表達(dá)系統(tǒng)制備，目的基因編碼的Gln26-Ala167在C端含有His標(biāo)簽。

CXCL15/Lungkine質(zhì)量控制：＞95%(還原性SDS-PAGE)。

CXCL15/Lungkine制劑：凍干品

CXCL15/Lungkine保存：
凍干蛋白可在-20℃長(zhǎng)期保存，室溫也可穩(wěn)定保存3周。
復(fù)溶蛋白溶液可在4～7℃保存2～7天。
復(fù)溶后建議分裝凍存在-20℃，可保存3個(gè)月，應(yīng)避免反復(fù)凍融。

CXCL15/Lungkine復(fù)溶：
1、試劑開蓋前請(qǐng)先離心。
2、復(fù)溶濃度應(yīng)大于100 μg/ml.
3、凍干蛋白溶于ddH2O中
4、復(fù)溶后根據(jù)使用量分裝保存，避免反復(fù)凍融。

關(guān)于CXCL15/Lungkine ：
Mouse C-X-C motif chemokine 15, also known as Cxcl15, is a secreted protein which is member of the ELR motif-containing CXC chemokines. It expressed at low levels in fetal lung, the expression restricted to the lung, produced by bronchoepithelial cells and is released into the airways. It plays an important role in lung-specific neutrophil trafficking during normal and inflammatory conditions. It also appears chemotactic for neutrophils.

名稱：重組人腫瘤壞死因子α(N端His標(biāo)簽)
貨號(hào)：JN0468
規(guī)格：10μg|50μg|500μg|1mg
本品由我們的大腸桿菌表達(dá)系統(tǒng)制備而成，目的基因編碼的Gly57-Leu233在N端含有His標(biāo)簽。

TNF-alpha質(zhì)量控制：＞95%(還原性SDS-PAGE)

TNF-alpha制劑：凍干品

TNF-alpha保存：
凍干蛋白置于-20℃以下可長(zhǎng)期保存，室溫條件下可穩(wěn)定保存3周。
復(fù)溶蛋白溶液可在4～7℃保存2～7天，可分裝后置于-20℃保存三個(gè)月。

TNF-alpha復(fù)溶：
打開試劑管前請(qǐng)先離心。
復(fù)溶濃度推薦大于100 μg/ml。
凍干蛋白請(qǐng)溶于ddH2O。
復(fù)溶后，請(qǐng)根據(jù)用量分裝凍存，避免反復(fù)凍融。

關(guān)于TNF-alpha：
Tumor Necrosis Factor-α (TNF-α) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressing CD4 secrete TNF-α while cells that express CD8 secrete little or no TNF-α. Synthesis of TNF-α can be induced by many different stimuli including interferons, IL2, and GM-CSF. The clinical use of the potent anti-tumor activity of TNF-α has been limited by the proinflammatory side effects such as fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF-α mutants with low systemic toxicity has been of intense pharmacological interest. Human TNF-α that binds to murine TNF-R55 but not murine TNF-R7, exhibits retained anti-tumor activity and reduced systemic toxicity in mice compared with murine TNF-α, which binds to both murine TNF receptors. based on these results, many TNF-α mutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro and have exhibited lower systemic toxicity in vivo. Recombinant Human TNF-α High Active Mutant differs from the wild-type by amino acid subsitution of amino acids 1-7 with Arg8, Lys9, Arg10 and Phe157. This mutant form has been shown to have increased activity with less inflammatory side effects in vivo.

關(guān)注重組小鼠TIGIT，重組小鼠T cell Immunoreceptor with Ig and ITIM domains，重組小鼠TIGIT，Recombinant Mouse T cell Immunoreceptor with Ig and ITIM domains，重組T cell Immunoreceptor with Ig and ITIM domains，JN1420，百奧萊博，，的同時(shí)，為您推薦更多您可能感興趣的產(chǎn)品：


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JN0267 重組人化生長(zhǎng)因子β2(TGF-β2) 10μg|50μg|500μg|1mg
JN0397 重組人白介素7受體α( IL-7Rα) 10μg|50μg|500μg|1mg
JN0511 重組小鼠CD30(TNFRSF8) 10μg|50μg|500μg|1mg
JN0521 重組人上皮細(xì)胞粘附分子(Ep-CAM) 10μg|50μg|500μg|1mg
JN0598 重組人血清淀粉樣P成分(SAP) 10μg|50μg|500μg|1mg

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