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產(chǎn)品名稱:重組人TSLP(胸腺基質(zhì)淋巴細(xì)胞生成素)
英文名稱:Recombinant Human Thymic stromal lymphopoietin
產(chǎn)品貨號(hào):JN1392
產(chǎn)品規(guī)格:10μg|50μg|500μg|1mg
本品由我們的大腸桿菌表達(dá)系統(tǒng)制備而成,目的基因編碼的Tyr29-Gln159表達(dá)純化得來(lái)。
TSLP質(zhì)量控制:>95%(還原性SDS-PAGE)
TSLP制劑:凍干品
TSLP保存:
凍干蛋白置于-20℃以下可長(zhǎng)期保存,室溫條件下可穩(wěn)定保存3周。
復(fù)溶蛋白溶液可在4~7℃保存2~7天,可分裝后置于-20℃保存三個(gè)月。
TSLP復(fù)溶:
打開(kāi)試劑管前請(qǐng)先離心。
復(fù)溶濃度推薦大于100 μg/ml。
凍干蛋白請(qǐng)溶于ddH2O。
復(fù)溶后,請(qǐng)根據(jù)用量分裝凍存,避免反復(fù)凍融。
關(guān)于TSLP:
Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino acids (aa) signal sequence and 131 aa mature region. Human TSLP has two isoforms lfTSLP (159 aa) and sfTSLP (63 aa) produced by alternative splicing . lfTSLP (159aa) is expressed in a number of tissues including heart, liver and prostate, and sfTSLP (63aa) is predominantly expressed in keratinocytes of oral mucosa, skin and in salivary glands. In aa sequence level, Human TSLP displays a
bout 43% identity with mouse TSLP. Thymic stromal lymphopoietin (TSLP) is a cytokine that functions mainly on myeloid cells; it induces the release of T cell-attracting chemokines from mo
nocytes and enhances the maturation of CD11c(+) dendritic cells . TSLP has proliferative effects on the myeloid cell line and may initiate asthma or atopic dermatitis respo
nses by directly activating mast cells . TSLP signals cells via the interleukin-7 receptor-α chain (IL-7Rα), shared with IL-7, together with the TSLP receptor (TSLPR) subunit. Recent studies indicate that TSLP and its receptor are novel therapeutic targets for rheumatoid arthritis , for increased intraarticular TSLP co
ncentrations in patients has caused chemotaxis and activation of arthritogenic T cells.
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關(guān)注
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