我公司致力于為客戶提供高純度、低成本的活性重組蛋白，包括重組人GABA受體相關(guān)蛋白在內(nèi)的各類受體、細(xì)胞因子、生長因子、轉(zhuǎn)錄因子、激素、酶、毒性蛋白、病毒抗原等。...

特別提示：包括重組人GABA受體相關(guān)蛋白(GABARAP)在內(nèi)，本公司的所有產(chǎn)品僅可用于科研實(shí)驗(yàn)，嚴(yán)禁用于臨床醫(yī)療及其他非科研用途！

產(chǎn)品名稱：重組人GABA受體相關(guān)蛋白(GABARAP)
英文名稱：Recombinant Human GABA(A) Receptor-Associated Protein
產(chǎn)品貨號：JN1937
產(chǎn)品規(guī)格：10μg|50μg|500μg|1mg

本品由我們的大腸桿菌表達(dá)系統(tǒng)制備而成，目的基因編碼的Met1-Lys117在N端帶有GST標(biāo)簽。

GABARAP質(zhì)量控制：＞95%(還原性SDS-PAGE)

GABARAP制劑：凍干品

GABARAP保存：
凍干蛋白置于-20℃以下可長期保存，室溫條件下可穩(wěn)定保存3周。
復(fù)溶蛋白溶液可在4～7℃保存2～7天，可分裝后置于-20℃保存三個月。

GABARAP復(fù)溶：
打開試劑管前請先離心。
復(fù)溶濃度推薦大于100 μg/ml。
凍干蛋白請溶于ddH2O。
復(fù)溶后，請根據(jù)用量分裝凍存，避免反復(fù)凍融。

關(guān)于GABARAP：
Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. GABARAP clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development, differentiation, growth regulation and tissue remodeling in multicellular organisms. An important inhibitory neurotransmitter, GABA, acts on GABA receptors that are ubiquitously expressed in the CNS. GABARAP has been shown to play a important role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton.

根據(jù)您的關(guān)注的重組人GABA受體相關(guān)蛋白(GABARAP)，重組GABA(A) Receptor-Associated Protein，rGABARAP，重組人GABA(A) Receptor-Associated Protein，GABARAP，重組GABARAP，重組人GABA受體相關(guān)蛋白(GABARAP)，rhGABARAP，Recombinant Human GABA(A) Receptor-Associated Protein，重組人GABA受體相關(guān)蛋白，重組GABA受體相關(guān)蛋白，重組人GABARAP，JN1937，百奧萊博，，，您可能還對以下產(chǎn)品有需求：

貨號	名稱	規(guī)格
JN1901	重組人瘦素蛋白	10μg|50μg|500μg|1mg
JN1928	重組人Esterase D	10μg|50μg|500μg|1mg
JN2031	重組人原肌球蛋白α1鏈(TPM1)	10μg|50μg|500μg|1mg
JN0514	重組人碳酸酐酶10(CA10)	10μg|50μg|500μg|1mg
JN0620	重組人VSIG4(含V-set和Ig結(jié)構(gòu)域蛋白4)	10μg|50μg|500μg|1mg
JN0621	重組人脂聯(lián)素(Adiponectin)	10μg|50μg|500μg|1mg

關(guān)注重組人GABA受體相關(guān)蛋白(GABARAP)，重組GABA(A) Receptor-Associated Protein，rGABARAP，重組人GABA(A) Receptor-Associated Protein，GABARAP，重組GABARAP，重組人GABA受體相關(guān)蛋白(GABARAP)，rhGABARAP，Recombinant Human GABA(A) Receptor-Associated Protein，重組人GABA受體相關(guān)蛋白，重組GABA受體相關(guān)蛋白，重組人GABARAP，JN1937，百奧萊博，，的同時，為您推薦更多您可能感興趣的產(chǎn)品：



名稱：重組人MANF(含His標(biāo)簽)
貨號：JN0208
規(guī)格：10μg|50μg|500μg|1mg
本品由我們的哺乳動物表達(dá)系統(tǒng)制備，目的基因編碼的Leu25-Leu182在C端含有His標(biāo)簽。

MANF質(zhì)量控制：＞95%(還原性SDS-PAGE)。

MANF制劑：凍干品

MANF保存：
凍干蛋白可在-20℃長期保存，室溫也可穩(wěn)定保存3周。
復(fù)溶蛋白溶液可在4～7℃保存2～7天。
復(fù)溶后建議分裝凍存在-20℃，可保存3個月，應(yīng)避免反復(fù)凍融。

MANF復(fù)溶：
1、試劑開蓋前請先離心。
2、復(fù)溶濃度應(yīng)大于100 μg/ml.
3、凍干蛋白溶于ddH2O中
4、復(fù)溶后根據(jù)使用量分裝保存，避免反復(fù)凍融。

關(guān)于MANF：
Mesencephalic astrocyte-derived neurotrophic factor(MANF) is a secreted protein which belongs to the ARMET family. MANF selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. It modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. MANF enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. MANF inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. The N-terminal region of ARMET may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. MANF reduces endoplasmic reticulum (ER) stress and has neurotrophic effects on dopaminergic neurons. Intracortical delivery of recombinant MANF protein protects tissue from ischemic brain injury. MANF has been described as a survival factor for dopaminergic neurons. MANF and a homologous protein, the conserved dopamine neurotrophic factor (CDNF), form a novel evolutionary conserved family of neurotrophic factors. MANF expression was widespread in the nervous system and non-neuronal tissues.

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