| 提交詢價(jià)信息 |
| 發(fā)布緊急求購 |
價(jià)格：電議
所在地：上海
型號(hào)：2114
更新時(shí)間：2013-07-27
瀏覽次數(shù)：802
公司地址：
(女士)
| No. | Size | Price |
| 2114P | 40 ul (4 western blots) | 詢價(jià) |
| 2114S | 100 ul (10 western blots) | 詢價(jià) |
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
| W | H M R Mk | Endogenous | 200 | Rabbit IgG |
Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals (1). mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GβL and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GβL, Sin1, and rictor (1). The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro (2). This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes (3). This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR (4).
關(guān)鍵詞：CST，抗體，一抗{byao_back}{byao_back2}
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免責(zé)聲明：以上所展示的[2114 Rictor (53A2) Rabbit mAb #2114]信息由會(huì)員[]自行提供，內(nèi)容的真實(shí)性、準(zhǔn)確性和合法性由發(fā)布會(huì)員負(fù)責(zé)。
