產(chǎn)品簡(jiǎn)介
"上海博耀生物銷(xiāo)售Histone Deacetylase 4 (HDAC4) Antibody #2072，CST原裝品質(zhì)，價(jià)格優(yōu)惠，訂購(gòu)Histone Deacetylase 4 (HDAC4)
產(chǎn)品說(shuō)明
"上海博耀生物銷(xiāo)售
Histone Deacetylase 4 (HDAC4) Antibody #2072，CST原裝品質(zhì)，價(jià)格優(yōu)惠，訂購(gòu)
Histone Deacetylase 4 (HDAC4) Antibody #2072，詳情請(qǐng)咨詢銷(xiāo)售人員！
產(chǎn)品詳細(xì)參數(shù)如下>>>>
產(chǎn)品名稱(chēng)：Histone Deacetylase 4 (HDAC4) Antibody #2072
貨號(hào)：2072
品牌：CST(cell signaling)
抗體來(lái)源：Rabbit
克隆類(lèi)型：
Polyclonal
規(guī)格：
| No. |
Size |
Price |
| 2072S |
100 ul (10 western blots) |
詢價(jià) |
抗體應(yīng)用：
| Applications |
Reactivity |
Sensitivity |
MW (kDa) |
Source |
| W |
H M R Mk |
Endogenous |
140 |
Rabbit |
Applications Key:
W=Western Blotting
Reactivity Key:
H=Human
M=Mouse
R=Rat
Mk=Mon
key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特異性/敏感度：
Histone Deacetylase 4 (HDAC4) Antibody detects endogenous levels of total HDAC4 protein. This antibody detects only HDAC4 protein; it does not cross-react with other HDAC proteins.
來(lái)源及純化方法：
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding amino acid 10 of human HDAC4. Antibodies are purified by protein A and peptide affinity chromatography.
抗體背景：
Acetylation of the histone tail causes chromatin to adopt an "open" conformation, allowing increased accessibility of transcription factors to DNA. The identification of histone acetyltransferases (HATs) and their large multiprotein complexes has yielded important insights into how these enzymes regulate transcription (1,2). HAT complexes interact with sequence-specific activator proteins to target specific genes. In addition to histones, HATs can acetylate nonhistone proteins, suggesting multiple roles for these enzymes (3). In contrast, histone deacetylation promotes a "closed" chromatin conformation and typically leads to repression of gene activity (4). Mammalian histone deacetylases can be divided into three classes on the basis of their similarity to various yeast deacetylases (5). Class I proteins (HDACs 1, 2, 3, and 8) are related to the yeast Rpd3-like proteins, those in class II (HDACs 4, 5, 6, 7, 9, and 10) are related to yeast Hda1-like proteins, and class III proteins are related to the yeast protein Sir2. Inhibitors of HDAC activity are now being explored as potential therapeutic cancer agents (6,7).
關(guān)鍵詞：CST，抗體，一抗{byao_back}{byao_back2}
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