產品簡介
"上海博耀生物銷售eIF4E (C46H6) Rabbit mAb #2067，CST原裝品質，價格優惠，訂購eIF4E (C46H6) Rabbit mAb #2067，詳情請咨詢銷
產品說明
"上海博耀生物銷售
eIF4E (C46H6) Rabbit mAb #2067，CST原裝品質，價格優惠，訂購
eIF4E (C46H6) Rabbit mAb #2067，詳情請咨詢銷售人員！
產品詳細參數如下>>>>
產品名稱：eIF4E (C46H6) Rabbit mAb #2067
貨號：2067
品牌：CST(cell signaling)
抗體來源：Rabbit
克隆類型：
Monoclonal
規格：
| No. |
Size |
Price |
| 2067P |
40 ul (4 western blots) |
詢價 |
| 2067S |
100 ul (10 western blots) |
詢價 |
抗體應用：
| Applications |
Reactivity |
Sensitivity |
MW (kDa) |
Isotype |
| W IP IHC-P |
H M R Mk |
Endogenous |
25 |
Rabbit IgG |
Applications Key:
W=Western Blotting
IP=Immunoprecipitation
IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key:
H=Human
M=Mouse
R=Rat
Mk=Mon
key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特異性/敏感度：
eIF4E (C46H6) Rabbit mAb detects endogenous levels of total eIF4E protein.
來源及純化方法：
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to human eIF4E protein.
抗體背景：
Eukaryotic initiation factor 4E (eIF4E) binds to the mRNA cap structure to mediate the initiation of translation (1,2). eIF4E interacts with eIF4G, a scaffold protein that promotes assembly of eIF4E and eIF4A into the eIF4F complex (2). eIF4B is thought to assist the eIF4F complex in translation initiation. Upon activation by mitogenic and/or stress stimuli mediated by Erk and p38 MAPK, Mnk1 phosphorylates eIF4E at Ser209 in vivo (3,4). Two Erk and p38 MAPK phosphorylation sites in mouse Mnk1 (Thr197 and Thr202) are essential for Mnk1 kinase activity (3). The carboxy-terminal region of eIF4G also contains serum-stimulated phosphorylation sites, including Ser1108, Ser1148, and Ser1192 (5). Phosphorylation at these sites is blocked by the PI3 kinase inhibitor LY294002 and by the FRAP/mTOR inhibitor rapamycin.
關鍵詞：CST，抗體，一抗{byao_back}{byao_back2}
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免責聲明：以上所展示的[2067 eIF4E (C46H6) Rabbit mAb #2067]信息由會員[]自行提供，內容的真實性、準確性和合法性由發布會員負責。
