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推薦：GLP1類似蛋白Exendin4抗體用途

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更新日期：2023-02-02 14:00
瀏覽次數：126 下載次數：138

詳細介紹

中文名稱    GLP1類似蛋白Exendin4抗體

英文名稱    Exendin 4

別    名    Exendin 4; Exendin4; Exendin-4; EXE4_HELSU .

供應商    遠慕生物

研究領域    免疫學神經生物學糖尿病

抗體來源    Rabbit

克隆類型    Polyclonal

交叉反應    Gila monster lizard

產品應用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 GLP1類似蛋白Exendin4抗體（石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量    4.3kDa

性    狀    Lyophilized or Liquid

濃    度    1mg/1ml

免疫原    KLH conjugated synthetic peptide derived from Gila monster lizard Exendin 4

亞    型    IgG

純化方法    affinity purified by Protein A

儲存液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

GLP1類似蛋白Exendin4抗體產品介紹    background:

Exendin 4 is a 39 amino acid peptide found in venom from the Gila monster Helicoderma suspectum. It is a member of the glucagon secretin family of peptide hormones and neuropeptides. Exendin 4 is a potent agonist of the GLP1 receptor and hence a potent stimulator of insulin secretion.

Function:
Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed by the venom gland.

Similarity:
Belongs to the glucagon family.

Database links:
UniProtKB/Swiss-Prot: P26349.2

important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.