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文獻：嗜酸性粒細胞過氧化物酶抗體應用方法

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更新日期：2022-11-28 14:13
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詳細介紹

中文名稱    嗜酸性粒細胞過氧化物酶抗體

英文名稱    EPX

別    名    Eosinophil peroxidase; Eosinophil peroxidase heavy chain; EPER; EPO; EPP; EPX PEN; PERE; PERE_HUMAN.

供應商    遠慕生物

研究領域    腫瘤  免疫學

抗體來源    Rabbit

克隆類型    Polyclonal

交叉反應    Human, Mouse, Rat,

產品應用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 嗜酸性粒細胞過氧化物酶抗體（石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量    79kDa

性    狀    Lyophilized or Liquid

濃    度    1mg/1ml

免疫原    KLH conjugated synthetic peptide derived from human Eosinophil peroxidase heavy chain

亞    型    IgG

純化方法    affinity purified by Protein A

儲存液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

嗜酸性粒細胞過氧化物酶抗體產品介紹    background:

EPX, eosinophil peroxidase, is an antimycobacterial protein that localizes to cytoplasmic granules of eosinophils and recruits bromide to generate a halogenating oxidant. EPX dependent generation of hypobromous acid causes damage to tissue during inflammatory conditions that include asthma, allergies,cancer and parasitic/helminthic infections. EPX is a major enzyme present in eosinophils and upon degranulation, becomes released into the airways of asthmatics. As a result of its cationic nature and its ability to catalyze the formation of highly toxic oxidants, EPX can induce lung injury in a JNK dependent manner.

Function:
Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.

Subunit:
Tetramer of two light chains and two heavy chains.

Subcellular Location:
Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils.

DISEASE:
Defects in EPX are the cause of eosinophil peroxidase deficiency (EPD) [MIM:261500]. EPD is an autosomal recessive defect where anomalous eosinophils are characterized by nuclear hypersegmentation, hypogranulation, and negative peroxidase and phospholipid staining.

Similarity:
Belongs to the peroxidase family. XPO subfamily.

Database links:
UniProtKB/Swiss-Prot: P11678.2

important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.