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S期激酶活化蛋白DBF4B抗體簡(jiǎn)介說(shuō)明

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更新日期：2021-12-24 14:32
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詳細(xì)介紹

英文名稱    DBF4B
中文名稱    S期激酶活化蛋白DBF4B抗體
別    名    Activator of S phase kinase like protein 1; ASK like protein 1; ASKL1; chifb; Chiffon homolog B; DBF 4B; DBF4 homolog B (S. cerevisiae); DBF4 homolog B; Dbf4 related factor 1; DRF1; Protein DBF4 homolog B; ZDBF1B; Zinc finger DBF type containing 1B; DBF4B_HUMAN.
規(guī)    格    0.2ml
研究領(lǐng)域    腫瘤細(xì)胞生物免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞周期蛋白激酶和磷酸酶表觀遺傳學(xué)
抗體來(lái)源    Rabbit
克隆類型    Polyclonal
交叉反應(yīng)    Human,
產(chǎn)品應(yīng)用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 S期激酶活化蛋白DBF4B抗體（石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分子量    18kDa
細(xì)胞定位    細(xì)胞核
性    狀    Lyophilized or Liquid
濃    度    1mg/1ml
免疫原    KLH conjugated synthetic peptide derived from human DBF4B/ASKL1
亞    型    IgG
純化方法    affinity purified by Protein A
儲(chǔ) 存液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

S期激酶活化蛋白DBF4B抗體產(chǎn)品介紹    background:
DBF4B is a regulatory subunit for CDC7, a serine-threonine kinase which links cell cycle regulation to genome duplication. The complex CDC7-DBF4B selectively phosphorylates the MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle. DBF4B localizes to the nucleus and its expression is cell cycle-regulated.

Function:
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.

Subunit:
Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4/DBF4A or DBF4B. Such complexes are stable upon replication stress.

Subcellular Location:
Nucleus. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction.

Tissue Specificity:
Widely expressed. Highly expressed in testis.

Post-translational modifications:
Phosphorylated.