甲狀腺素5'脫碘酶3抗體應用說明
 |
|
- 更新日期：2021-12-02 15:11
- 瀏覽次數：232 下載次數：111
|
 |
詳細介紹
中文名稱 甲狀腺素5'脫碘酶3抗體
英文名稱 Dio3
別 名 Type 3 DI; D3; 5DIII; Deiodinase iodothyronine type 3; Deiodinase iodothyronine type III; Dio 3; DIOIII; MGC124117; MGC124118; TXDI3; Type III 5' deiodinase; Type III iodothyronine deiodinase.
研究領域 腫瘤 細胞生物 免疫學 染色質和核信號 生長因子和激素 轉錄調節因子
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
產品應用 WB=1:500-2000 ELISA=1:500-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
細胞定位 細胞膜
性 狀 Lyophilized or Liquid
濃 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Dio3:51-150/278
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
產品介紹 Dio3 belongs to the iodothyronine deiodinase family. It has an essential role for regulation of thyroid hormone inactivation during embryological development in that it catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. Dio3 may play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones and has been linked to the development of consumptive hypothyroidism in both infants and adults.
抗體優點：
①耐熱、耐酸、耐堿、抗有機溶劑以及金屬離子，穩定性好，室溫下可以長期保存；
②制備簡單，操作方便，可以進行批量生產；
③不必免疫動物，且可獲得免疫動物所不能得到的“抗體”；
④可以反復使用；
⑤價格低廉。因此，設計、合成既具有類似生物抗體的高親合性和高專一性，又具有耐熱、耐酸、耐堿且又可以長期穩定的人工抗體，在部分領域替代生物抗體以進行仿生分子識別，或者完成一些生物抗體所不能完成的工作，具有重要的科學意義，在化學、生命科學和環境科學等方面具有廣闊的應用前景。
[ 資料搜索 ]
[ ]
[ 告訴好友 ]
[ 打印本文 ]
[ 關閉窗口 ]
[ 返回頂部 ]
