產品簡介
Catalogue Number CYT-580 Synonyms Pigment epit
公司簡介
上海亞培生物科技有限公司，是一家專注于生命科學和生物技術領域的高科技企業，專業提供分子生物學、免疫學、生命科學基礎研究以及臨床檢測等諸多領域的試劑、耗材、儀器等各類產品及生物技術服務。 公司一方面注意跟蹤世界范圍分子生物學、細胞生物學等生物學科的發展前沿，努力將歐美專業生產廠家的具有國際先進水平的產品推薦給各類研究人員；另一方面也非常重視自主產品研究和開發，推出了一系列具有競爭力的產品和服務。公司客戶遍布大學、研究所、醫院、衛生防疫、商品檢驗檢疫、制藥公司、生物技術公司和食品工業等單位。 公司在重視產品質量的同時，也建立了一套集技術支持、物流、售后服務等多個部門的全方位的服務體系，努力把我們方便、快捷、周到的服務提供給每一個客戶。我們的目標是讓亞培成為在生命科學和生物技術領域內集生產、研究開發和銷售于一體的國內外知名的一流企業每一個亞培人，都心存一個信念：希望通過自身的不懈努力，通過我們優秀的產品、專業的服務來更好的服務用戶，為我們每一個用戶的成功鋪路搭橋，也為亞培的成功鋪路搭橋！
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產品說明
| Catalogue Number |
CYT-580 |
| Synonyms |
Pigment epithelium-derived factor,PEDF, Serpin-F1, SerpinF1, EPC-1, EPC1, PIG35. |
| Introduction |
PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. PEDF is a 50,000 dalton glycoprotein created and secreted in many tissues all the way through the body. A key component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. Additionally, PEDF is capable to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuro-protective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recognition of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities associate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF in addition has the potential to be functional in the treatment of various angiogenesis-related diseases including a number of cancers. |
| Description |
PEDF Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 400 amino acids and having a molecular mass of 44.5 kDa.
The Human PEDF is purified by proprietary chromatographic techniques. |
| Source |
Escherichia Coli. |
| Physical Appearance |
Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation |
The sterile filtered concentrated (1mg/ml) protein solution was lyophilized with 20mM sodium phosphate buffer & 150mM NaCl pH-7.4. |
| Solubility |
Add deionized water to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely. |
| Stability |
Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/ thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time. |
| Purity |
Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence |
MQNPASPPEEGSPDPDSTGALVEEEDPFFKVPVNKLAAAVSNFGYDLYRVR
SSMSPTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISSPDIHGTYK
ELLDTVTAPQKNLKSASRIVFEKKLRIKSSFVAPLEKSYGTRPRVLTGNPRLD
LQEINNWVQAQMKGKLARSTKEIPDEISILLLGVAHFKGQWVTKFDSRKTS
LEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSIIFFLPL
KVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLLSYEGEVTKSLQEMKL
QSLFDSPDFSKITGKPIKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPL
DYHLNQPFIFVLRDTDTGALLFIGKILDPRGP. |
| Usage |
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
| Related Products |
| » PEDF Antibody |
| » PEDF Human, HEK |
| » PEDF Human, His |
|
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Tris Buffer grade Tris緩沖液 500g
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Rhodamine 6G (C.I. 45160) 羅丹明6G 25g
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Fuchsin basic (C.I. 42510) Microscopy grade 品紅/洋紅 堿性 25g
Crystal violet (C.I. 42555) 結晶紫 25g
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TaqDNA Taq DNA聚合酶（4支一套） 1,000U
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rIL-6 重組大鼠白介素-6 2µg
mVEGF 重組小鼠血管內皮生長因子 2µg
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PEDF 重組人色素上皮衍生因子 20µg
Human IL-2 重組人白介素-2 10µg
Activin-A 重組人活化素-A 2µg
IL-4 重組人白介素-4 2µg
EPO-a 重組人紅細胞生成素-a 5µg
rIL-2 重組大鼠白介素-2 5µg
IL 13 重組人白介素-13 2µg
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mGMCSF 重組小鼠粒細胞巨噬細胞集落刺激因子 2μg
rIL 1 beta 重組大鼠白介素-1β 2µg
rpTNF-a 重組豬腫瘤壞死因子-a 5µg
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免責聲明：以上所展示的[貨號CYT-580 重組人色素上皮衍生因子]信息由會員[上海亞培生物科技有限公司]自行提供，內容的真實性、準確性和合法性由發布會員負責。
